44 research outputs found
Reliable Collaborative Filtering on Spatio-Temporal Privacy Data
Lots of multilayer information, such as the spatio-temporal privacy check-in data, is accumulated in the location-based social network (LBSN). When using the collaborative filtering algorithm for LBSN location recommendation, one of the core issues is how to improve recommendation performance by combining the traditional algorithm with the multilayer information. The existing approaches of collaborative filtering use only the sparse user-item rating matrix. It entails high computational complexity and inaccurate results. A novel collaborative filtering-based location recommendation algorithm called LGP-CF, which takes spatio-temporal privacy information into account, is proposed in this paper. By mining the users check-in behavior pattern, the dataset is segmented semantically to reduce the data size that needs to be computed. Then the clustering algorithm is used to obtain and narrow the set of similar users. User-location bipartite graph is modeled using the filtered similar user set. Then LGP-CF can quickly locate the location and trajectory of users through message propagation and aggregation over the graph. Through calculating users similarity by spatio-temporal privacy data on the graph, we can finally calculate the rating of recommendable locations. Experiments results on the physical clusters indicate that compared with the existing algorithms, the proposed LGP-CF algorithm can make recommendations more accurately
Breaking the amyotrophic lateral sclerosis early diagnostic barrier: the promise of general markers
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is associated with selective and progressive loss of motor neurons. As a consequence, the symptoms of ALS are muscle cramps and weakness, and it eventually leads to death. The general markers for early diagnosis can assist ALS patients in receiving early intervention and prolonging their survival. Recently, some novel approaches or previously suggested methods have validated the potential for early diagnosis of ALS. The purpose of this review is to summarize the status of current general markers discovery and development for early diagnosis of ALS, including genes, proteins neuroimaging, neurophysiology, neuroultrasound, and machine learning models. The main genetic markers evaluated are superoxide dismutase 1 (SOD1), chromosome 9 open reading frame 72 (C9orf72), transactivation-responsive DNA binding protein 43 (TARDBP), and fused in sarcoma (FUS) genes. Among proteins, neurofilament light chain is still the most established disease-specific adaptive change in ALS. The expression of chitinases, glial fibrillary acidic protein (GFAP), and inflammatory factors are changed in the early stage of ALS. Besides, more patient-friendly and accessible feature assays are explored by the development of neuroimaging, neurophysiology, and neuroultrasound techniques. The novel disease-specific changes exhibited the promising potential for early diagnosis of ALS. All of these general markers still have limitations in the early diagnosis, therefore there is an urgent need for the validation and development of new disease-specific features for ALS
Ellipticity-dependent sequential over-barrier ionization of cold rubidium
We perform high-resolution measurements of momentum distribution on Rb
recoil ions up to charge state , where laser-cooled rubidium atoms are
ionized by femtosecond elliptically polarized lasers with the pulse duration of
35 fs and the intensity of 3.310 W/cm in the over-barrier
ionization (OBI) regime. The momentum distributions of the recoil ions are
found to exhibit multi-band structures as the ellipticity varies from the
linear to circular polarizations. The origin of these band structures can be
explained quantitatively by the classical OBI model and dedicated classical
trajectory Monte Carlo simulations with Heisenberg potential. Specifically,
with back analysis of the classical trajectories, we reveal the ionization time
and the OBI geometry of the sequentially released electrons, disentangling the
mechanisms behind the tilted angle of the band structures. These results
indicate that the classical treatment can describe the strong-field multiple
ionization processes of alkali atoms
Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered
progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions
of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets
for sepsis therapeutics, we used samples for miRNA array analysis of PBMCs from patients with sepsis and control
individuals, blood samples from 2 cohorts of patients with sepsis, and multiple animal models: mouse cecum ligation
puncture–induced (CLP-induced) sepsis, mouse viral miRNA challenge, and baboon Gram+
and Gram–
sepsis models.
miR-93-5p met the criteria for a therapeutic target, as it was overexpressed in baboons that died early after induction of
sepsis, was downregulated in patients who survived after sepsis, and correlated with negative clinical prognosticators for
sepsis. Therapeutically, inhibition of miR-93-5p prolonged the overall survival of mice with CLP-induced sepsis, with a
stronger effect in older mice. Mechanistically, anti–miR-93-5p therapy reduced inflammatory monocytes and increased
circulating effector memory T cells, especially the CD4+
subset. AGO2 IP in miR-93–KO T cells identified important
regulatory receptors, such as CD28, as direct miR-93-5p target genes. In conclusion, miR-93-5p is a potential therapeutic
target in sepsis through the regulation of both innate and adaptive immunity, with possibly a greater benefit for elderly
patients than for young patients
Insight-HXMT observations of Swift J0243.6+6124 during its 2017-2018 outburst
The recently discovered neutron star transient Swift J0243.6+6124 has been
monitored by {\it the Hard X-ray Modulation Telescope} ({\it Insight-\rm HXMT).
Based on the obtained data, we investigate the broadband spectrum of the source
throughout the outburst. We estimate the broadband flux of the source and
search for possible cyclotron line in the broadband spectrum. No evidence of
line-like features is, however, found up to . In the absence of
any cyclotron line in its energy spectrum, we estimate the magnetic field of
the source based on the observed spin evolution of the neutron star by applying
two accretion torque models. In both cases, we get consistent results with
, and peak luminosity of which makes the source the first Galactic ultraluminous
X-ray source hosting a neutron star.Comment: publishe
Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite
As China's first X-ray astronomical satellite, the Hard X-ray Modulation
Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15,
2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy
satellite with the capability of all-sky monitoring in 0.2-3 MeV. It was
designed to perform pointing, scanning and gamma-ray burst (GRB) observations
and, based on the Direct Demodulation Method (DDM), the image of the scanned
sky region can be reconstructed. Here we give an overview of the mission and
its progresses, including payload, core sciences, ground calibration/facility,
ground segment, data archive, software, in-orbit performance, calibration,
background model, observations and some preliminary results.Comment: 29 pages, 40 figures, 6 tables, to appear in Sci. China-Phys. Mech.
Astron. arXiv admin note: text overlap with arXiv:1910.0443